QUANTUM SIGNALLING FOR CANCER CELL APOPTOSIS
One potential use of quantum biological tunneling is the modulation of biological functions. It is essential for processes such as cellular respiration. In order to control electron transport and induce cancer cell death, we have combined wireless nano-electrochemical instruments with cancer cells. By utilizing zinc porphyrin and cytochrome c-equipped gold bipolar nanoelectrodes, we have developed bio-nanoantennae that react to electrical fields and promote electron transit between these molecules. This results in quantum biological tunneling, which causes cancer cells generated from patients to undergo selective apoptosis. Transcriptomics results demonstrate electrically triggered molecular signaling control using a unique targeting method. This study emphasizes the use of quantum-based methods in medical diagnosis and therapy.
We are entering an era where bioelectricity, the cell's electrical language, governs cellular function through interconnected circuits using endogenous currents for communication and homeostasis. Quantum biological tunneling for electron transfer (QBET), seen in processes like photosynthesis and mediated by redox-active molecules such as cytochrome c (Cyt c), is crucial. Modulating these quantum effects could lead to disruptive quantum medicines for cancer treatment, but precise electrical-molecular communication within cells remains a technological challenge. Our study pioneers solutions by utilizing gold nanoparticles (GNPs) and carbon nanotubes as bipolar nanoelectrodes, termed bio-nanoantennae. These nanoelectrodes respond to external electric fields (EFs), enabling bio-signaling events via electrochemically induced redox reactions, potentially modulating electron transfer pathways.
By applying alternating current electric fields to molecules adhered to nanoantennae surfaces, we modified their redox state, drawing inspiration from wireless electrochemistry. In patient-derived glioblastoma (GBM) cells, this approach specifically improves electrical-molecular communication and induces death by modifying the redox state of cytochrome C in response to resonant electric fields. According to our research, quantum tunneling for electron transfer (QBET), which is caused by an electric field, is the mechanism by which electrons are transferred within these bio-nanoantennae. The linker length, frequency, and potential are critical variables in this process. The targeted character of electrical-molecular communication, particularly in cancer cells, is confirmed by transcriptomics research. This innovation presents a wireless electrical-molecular communication device that can target and eradicate cancer cells with efficacy.
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